Therapeutic Index

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MCW Advanced Pharmacology MSN 7703 Therapeutic Index The therapeutic index is a quantitative measurement of the relative safety of a drug and considers dose required for a toxic effect versus that required for the desired beneficial or therapeutic effect (Tamargo, Le Heuzey, & Mabo, 2015). It is the ratio of the dose that elicits a lethal response in 50% of treated individuals (LD50), divided by the dose that elicits a therapeutic response in 50% of the treated individuals (ED50). In short, the LD50 is the dose required to kill 50% of cases and the ED50 is the dose required to cure 50% of cases (Kang, 2016; Edmunds & Mayhew, 2009; Peterson, 2017).

Since the therapeutic index (TI) equals the LD50 divided by the ED50, in general, a larger therapeutic index indicates a safer drug and a...

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